Nolan's search for Irisa leads him to "New Chicago" and "Angel Arc" Los Angeles. Meanwhile, back in Defiance, the Earth Republic appoints a charming, calculating and ambitious man named Niles Pottinger as mayor.
Irisa is arrested upon her return to Defiance, but Nolan can arrange her release by capturing those responsible for an explosion that nearly killed Mayor Pottinger. Meanwhile, Stahma decides the only way to stay in control of her family's criminal enterprises is by ensuring that Datak stays behind bars.
Irisa continues to experience blackouts at a terrifying and increasing rate, but she tries to keep a worried Nolan in the dark about her situation; and under Stahma's self-appointed leadership, the Tarr family business prospers, while an increasingly suspicious Datak remains locked up behind bars.
Nolan is ordered to hunt down and destroy those responsible for a vicious attack in the badlands on a badly shaken Pottinger and his caravan. Tensions flare when Nolan's investigation turns up evidence implicating one of Rafe's miners. Meanwhile, Datak sets his vengeful sights on reclaiming control over the family business.
A stalker terrorizes Amanda.
An Arkfall crash salvage mission led by Nolan leads to danger in the form of an alien race he has never encountered before; at the same time, Stahma makes a shocking power play after she's admonished by church elders for her growing sense of female empowerment; and Irisa begins confessing her deep, dark secrets to Tommy.
Datak turns to an unlikely ally for help after he's framed for a bizarre murder; and a mysterious stranger leads Irisa to discover more about her destiny.
Nolan interrogates a suspected Votanis Collective spy in an effort to prevent a cataclysmic terrorist attack on New York.
Doc Yewll works to keep her dark secret from coming out.
A deadly mine collapse leaves Amanda and Pottinger trapped, and it's a race against the clock for Nolan and Rafe to save them.
Nolan searches for Irisa, leaving Amanda to take on the deputy's badge just as a shocking murder rocks Defiance.
Nolan races to save Tommy's life and stop Irisa; tensions between Amanda and Stahma lead to a showdown.
Season 2 comes to a close with Nolan fighting both the Earth Republic and old acquaintances to stop Irisa's destructive plan from becoming a reality. He's also determined to save his adoptive daughter from the Kaziri forces that have been possessing her before his own friends attempt to kill her.
