One Day In My Body – official series poster, TLC

One Day In My Body

TLC Running

1 Season · 8 Episodes · Premiered April 15, 2026

This bold and intimate series hands the camera to those living with some of the world's rarest medical conditions. Meet an individual allergic to water, a woman who ages at an unusually rapid rate, a woman who has been unable to empty her bladder in years, and other complex disorders that leave the most skilled medical professionals searching for answers.

Where to Watch: TLC

Official Site

Next Air Time: Thu, May 28 2026 1:00 AM GMT+0000

Seasons & Episodes

Season 1

8 episodes
E01
Half Man/Half Incredible
Thu, Apr 16 2026 1:00 AM GMT+0000 60 min
At just 18 years old, Loren was involved in a catastrophic forklift accident. To save his life, doctors cut him in half. Sofia was an active 29-year-old when her heart went into end-stage failure. Now she must be plugged-in to stay alive.
E02
Aged and Born Fused
Thu, Apr 23 2026 1:00 AM GMT+0000 60 min
Tiffany has progeria, a condition that causes her to age rapidly - yet she's already outlived her life expectancy. Single dad Ryan was born with Arthrogryposis, leaving his arms and legs fused. 
E03
The Halo Effect
Thu, Apr 30 2026 1:00 AM GMT+0000 60 min
Lukas has Parry-Romberg Syndrome, causing half his face to shrink inward. Stefani's rare muscular dystrophy leaves her dependent on her mother but craving independence. Ellie says steroid withdrawal left her with lizard skin and seeks a cure.
E04
Fading Confetti
Thu, May 7 2026 1:00 AM GMT+0000 60 min
An allergic reaction left Kirtus with vitiligo, alopecia, and bone loss. An upcoming surgery could change his life. Portia's rare skin condition may exist in fewer than 25 people worldwide. Dani lost all four limbs, and now she fights to walk unassisted.
E05
Speaking of Skin
Thu, May 14 2026 1:00 AM GMT+0000 60 min
There are only two foods that won't send Caroline into anaphylaxis; touching almost anything causes Ariana's butterfly skin to blister and tear; Aleazia's cystic hygroma caused his jaw and tongue to swell, permanently freezing his mouth open.
E06
Walk the Walk, Talk the Talk
Thu, May 21 2026 1:00 AM GMT+0000 60 min
Zahra is housebound by a rare condition, but new prosthetics may be her ticket to freedom. Mahogany's leg weighs nearly 100 pounds due to lymphedema. Joseph was born without a jaw but won't let it stop him.
E07
TBA
Thu, May 28 2026 1:00 AM GMT+0000 60 min
E08
TBA
Thu, Jun 4 2026 1:00 AM GMT+0000 60 min

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