Willy Moran, a drunk, is hired by a wagon as a driver. He is an army buddy of the Major, but is used as a fall guy by a member of the train who wants to rob it. When the battle starts, Willy uses his army skills to turn the battle.
When Seth comes to the aid of a man unjustly accused of murder, the dead man's father forbids the stores in St. Joseph from selling the train any supplies.
John Cameron heads west with his wife to start a new life. Her flirtatious ways may get the better of her when three trappers come into camp offering fresh buffalo and thinking she might be more available than she is.
Ruth Owens remarries and is moving west with her new husband. When her brother comes looking for her, he stirs up trouble for her about her past and himself because he just killed a man.
Just released from prison for murder, Les Rand goes back home to kill the man he held responsible; his father, the doctor. Meanwhile, Flint is there to fetch the doctor to help someone injured. Les vows that no one will stand in his way.
A pacifist since the war, Nels Stack stands up to any man prejudiced against another. When his own beliefs are tested in the face of an impending Indian attack against the wagon train, he has to decide who he is going to defend.
Emily Rossiter had a young daughter to care for. She met and married someone she felt she could trust. When she found out this was misplaced, getting the daughter away from him and into a better life becomes her main goal. Flint is sent in search of a gang of robbers who have stolen the wagon train money and deeds to land in California.
John Darro is revealed as the man who abandoned a wagon train to the Indians several years ago. John has to prove that he's not the coward that he's reputed to be.
Lieutenant Avery has a mission. Deliver a peace treaty and the chief's daughter. But he has a secret vendetta that may jeopardize everyone's hope for peace.
Mary Halstead is in search of a son she gave up a long time ago. With months to live, she comes west on the trail of someone who could be her son, but he may also turn out to be a notorious outlaw.
The wagon train stops in a newly built town to get water they had always been able to get before for free. Wanting money now, and at a steep price, has the Major upset. Sending Flint also uncovers a wife of a passenger thought dead.
Riley Gratton has always drifted from here to there, a smooth tongue getting him whatever he needed. When he tries to do the same with some folks on the Major's wagon train, what comes next may be the least of his worries.
When a new officer and troops kill an Indian brave and the post commander's drunken bored wife insults the Chief, Flint is forced to act as a neutral agent between the Army and Indians and save the wagon train.
A strong-willed woman, Julie Gage, runs into trouble when she's forced to "half marry" a man that she's tending to when he's stricken with fever.
Mortally wounded in a buffalo stampede, Cliff Grundy's friend Flint stays when the wagon train leaves. Manson says he will help but his reasons for staying become clear as Cliff keeps saying he has a goldmine somewhere and he's recovering.
A riverboat gambler who has committed murder pretends to be a parson traveling with his children.
The Cowans and Beals have been feuding a long time. Bob and Jesse return from the war and find their family dead and the Beals have joined a wagon train. Revenging their family is just the start of what Major Adams must now deal with.
An old Indian asks to join the wagon train so his son can learn the ways of the white man because he believes the Indian way of life is dying.
Don Charlie is a gambler and womanizer and makes no excuses for it. When he meets a woman who wants to marry him there may be trouble because the Major promised her uncle that she would make it safely to San Francisco.
Flint runs afoul of crooked soldiers selling guns to the Indians.
The MacGregor clan decides to come to America and start a new life. The wagon trains going to California have had a hard time dealing with their different customs. Can Major Adams' be any different?
An American Indian, his wife and baby join the wagon train when Major Adams discovers him badly beaten by bigoted white settlers.
A young Indian kidnaps his father's fiancé and forces her to work as revenge against the man who treated his mother badly and caused her suicide.
Revolutionary Bernal Sierra joins the train finding the wife of his dead friend married to Casey Reardon who sold guns to the Mexican revolutionaries. Bernal is suspicious of Casey, his brothers, and Perdita over missing gold.
A romantic triangle between Marie Dupree, Wiley Howard, and Tonio Gigli play out when the wagon train meets another one led by Wiley.
A white man who was captured by Indians, but eventually earned their respect and married his captor's sister, faces prejudice when he returns home to Boston.
During a storm, Flint takes shelter at a farmhouse. He soon discovers the husband is refusing his wife the care of a midwife and before it's too late for her he needs to find out why.
Sally Potter hitches a ride on the wagon train but being pretty helps and hurts her. Someone she knew catches up to the train and wants to remind her of who she is and where she came from, possibly ruining what she wants for her future.
Faith is tested when a man's wife is injured and he refuses medical aid. When Flint rides to the nearest town to get a doctor, he finds they have their own problems: a smallpox epidemic.
During the Civil War, Charlie Wooster joins Bill Hawks under the command of Major Seth Adams. When Adams is seriously wounded saving Hawks's life, he must struggle to survive, while dreaming of the girl he left behind.
Years after the Civil War, Major Adams gets a second chance with his lost love Ranie, who had married in his absence. But happiness doesn't always come easy, as a sinister rival and a dark secret attest.
Disguised as Yank soldiers, a band of confederate marauders blend into the wagon train, planning on robbing everyone. They are at first stopped but a member of the train helps the man in charge when she discovers the truth to his identity.
In a growing town, Seth meets a friend from his distant past. He remembers how they met and the circumstances bringing them west. When his friend's home is threatened, not ever wearing a gun surprisingly helps him rather than the reverse.
Ruttledge Munroe joins the wagon train on the trail. It's noticed right off his odd sense of humor, but when he saves the major's life, it is forgotten until he kills someone else and the real reason he joined up is revealed.
On one final push to the west, a wild west showman runs into some old friends. Some that were part of a massacre that almost cost them their lives and one man his sanity.
Trail hardened Cassie Tanner joins the train and sets her eye on Major Adams. But the train desperately needs horses, and she may be the only one who can make the dangerous journey to buy them.
Tensions are running high in the train between northerners and southerners traveling west. As trouble escalates one passenger with a noticeable limp, John Wilbot, is accused of being John Wilkes Booth, who many believe is still alive.
When the wagon train runs low on water, Adams is forced to rely on a suspected deserter to get help from a nearby fort.
At the end of a long journey, lives were lost. Some made it with their dreams intact. Flint tries to help two of the passengers with theirs and almost bites off too much. Politics are involved as well as unsolicited trips to the Far East.
