Doc is called to a farm to treat a sick farmer, who has always hated doctors.
Matt must resort to trickery after he and Chester trail psychopathic killer Lou Shippen to a small town whose citizenry is so frightened of Shippen that they refuse to even point him out.
"Rough justice" awaits cocksure Army deserter Joe Trimble after a civilian jury wrongly acquits him of murder and the Army forgoes prosecution in favor of returning him to his unit.
Matt goes on a rampage to close down Front Street after he accidentally shoots and kills his old friend (and temporary deputy) while trying to defend himself from a sneak attack by a murderous saloonkeeper.
After Matt beats fast gun and braggart Sam Kircher in a gunfight, Kircher's inexperienced teen brother comes to town and tells Matt he will learn to use a gun, and then kill him.
When a twelve-year-old Cheyenne prisoner is brought to Dodge by the Cavalry, a woman claims it's her son, who the tribe kidnapped many years earlier.
Matt is put in a difficult position by the arrival of Nick Search, an old friend who has since become a gambler with a fast draw and a reputation for dishonesty.
Doc comes upon a new homesteader confined to bed with a badly infected leg and a gun under the bedclothes for protection against his wife.
When a man suspected of murder can't establish his alibi, Matt arrests the man. After the prisoner draws a gun on Chester and escapes, evidence suggests he might not be guilty.
Killer Jed Butler takes Doctor Adams hostage to help his dying partner, and learns the true meaning of love for a friend, when Matt risks his life to rescue the good doctor.
Matt strongly suspects that it is actually white men who are responsible for a murderous series of "Indian raids" that have terrorized prairie-dwelling families.
A man is shot on the streets of Dodge, and Matt realizes that shot was meant for him.
A saloon gal past her youth suddenly receives two marriage proposals, one from a sweet country bumpkin, one from a menacing dandy, but it's no embarrassment of riches: each suitor threatens violence if she selects his rival.
A landowner's attempt to evict homesteaders is helped by a cholera outbreak.
A man, abandoned and permanently crippled by the cold on the prairie, is rescued by Matt and Chester and struggles to find a purpose.
Matt jails the wife abusing Sam Baxton on suspicion of murdering 2 squatters on his land, but after Baxton gets locked up, a 3rd squatter is murdered.
A white man and his Indian wife, passing through Dodge, become targets of violence after it is learned that the wife's father led deadly raids against white settlers.
A bank robber murders his partner and comes to Dodge with his terrified wife, hoping to keep a low profile, but an Indian he once humiliated won't let him be.
Grief-stricken rancher Morgan Curry proves willing to go to any length necessary to get revenge after cocksure gunman Tom Clegg kills his brother Abe in a needlessly provoked gunfight.
When Matt serves a warrant in another town for a wanted man, there are two men answering the possible suspect's description, and they both have gone totally straight.
The shooting of several members of an outlaw gang, though in self defense, triggers an emotional crisis in Matt, haunted by memories of all the men he has killed.
When a lady comes to town looking for her betrothed, Matt takes it upon himself to sober up the man, who, in his fiancée's absence, has become the town drunk.
Violence and tragedy result when Matt and Chester persuade a reluctant Kitty to hire flirtatious Rena Decker as a Long Branch hostess.
Told he has only two months to live, a man is determined to avenge the suicide of a young woman by killing the womanizer he blames for her death.
A government official from Washington warns Matt that he will relieve him of his duties if he does not start using a firmer hand in Dodge.
Miss Kitty is suspected of taking a shot at drunkard John Peavy for harassing her earlier, and shortly thereafter someone fires a shot at her.
When the drunkard whom Chester escorts to jail is shot dead, Chester is suspected of the murder.
Professor Jacoby is a photographer from back East in Dodge, willing to do anything for a picture, even to the point of committing murder.
Sam Rickers shot a man dead in the back to try and claim a $1,000 reward, but it turns out that the dead man was never wanted by the law.
A saloon gal's old beau is in town, and she expects trouble when he finds out where she is working.
A weird whiskey drummer named Wilbur Hawkins makes a claim to Matt that he overheard a man making a offer to pay 300 dollars to kill him, and shortly thereafter an attempt is made on Matt's life.
A man wants to marry a woman whose brother may be willing to resort to violence to keep her from leaving home.
Vint is a crooked card dealer being watched by a gunman hired by a card player to make sure he can not cheat, so he resorts to murder and robbery to recover his losses.
Despicable gunman Joe Delk provokes Lew and Billy Baxter and easily kills the inexperienced young men in gunfights, but Matt's swift and unexpected reaction soon has Delk experiencing nightmares and self-doubt.
Uncle Oliver arrives in town and believes his simpleton nephew would be a good deputy for Matt, instead of Chester.
Kitty's long-lost father, who abandoned her when she was a baby, shows up in Dodge, eager to take her back to New Orleans with him.
Major Emmett Egan has been approved for the job of marshal by the War Department. Matt agrees to let him have his job if Egan shadows him for a week to see if he can handle it.
Hank Shinn is a newcomer in town bragging about his reputation as a gunman, but Marshal Dillon suspects he is nothing more than a braggat and a liar.
A card dealer, newly married, wants to kill his old friend, Marshal Dillon, when a crooked gambler starts rumors that Dillon is courting the dealer's wife.
