Taye Diggs
as Dr. Sam Bennett
Paul Adelstein
as Dr. Cooper Freedman
Tim Daly
as Dr. Pete Wilder
KaDee Strickland
as Dr. Charlotte King
Kate Walsh
as Dr. Addison Forbes Montgomery
Amy Brenneman
as Dr. Violet Turner
Brian Benben
as Dr. Sheldon Wallace
Audra McDonald
as Dr. Naomi Bennett
Caterina Scorsone
as Dr. Amelia Shepherd
Chris Lowell
as William "Dell" Parker
Benjamin Bratt
as Dr. Jake Reilly
Griffin Gluck
as Mason Warner