On the series premiere of QUEEN OF THE SOUTH the Mexican drug cartel comes after Teresa Mendoza with a vengeance and she is forced to run and do whatever it takes to survive. Teresa's fate is sealed in the dangerous narco world forever and she has to prove her worth to Camila. Meanwhile, Epifanio gets closer in his hunt. Back in Mexico, Brenda desperately tries to find Teresa and hide from the cartel.
Still reeling from the loss of Guero's (Jon Ecker) and her escape to America, Teresa has to fend for herself and avoids being forced into prostitution by proving her worth to Camila. Epifanio's hunt for Teresa leads him to contact Camila. Meanwhile, in Mexico, Brenda, desperately tries to contact Teresa as she and Tony evade Epifanio's hit men.
Camila sends Teresa on a major drug operation to test her loyalty. When Teresa plays a pivotal role in the pickup, she takes a real step toward being trapped into Camila's dark narco world. Camila enlists Teo, a high-powered lawyer, to help her with first big secretive move into taking over Epifanio's cartel. Meanwhile, Brenda, still on the run, finally makes contact with Teresa, who helps her escape, but not how she expected.
An unexpected and deadly hiccup mars Teresa's first solo drug run, forcing James and Camila to clean up the mess. Teresa soon finds herself in further when one of Epifanio's hitmen, "Batman" (Gerardo Taracena) discovers that she's in Dallas, which also forces Camila to make a risky deal on Teresa's behalf. Meanwhile, Brenda and Tony arrive in Dallas.
Teresa advances her plans after witnessing a horrific incident; and Brenda, who's safely in Dallas, begins assembling a team to help her sell drugs.
Camila, who's deep in debt and short on supply, contemplates giving up Teresa; and Brenda's drug enterprise causes problems between her and Tony.
Camila sends Teresa on a dangerous mission; and Brenda, facing a supply shortage, puts her crew in the line of fire.
Camila attempts a risky heist; and Teresa is forced to make a life-changing decision while undercover.
Teresa tries to save a witness to the heist; and a confident Camila vows that she's back in business and is done with Epifanio.
Camila returns to Mexico in order to protect herself; James hunts Teresa; and Teresa faces danger while taking Maria through the tunnel to Mexico.
Camila's operation goes underground when James finally sets out to kill "The Birdman" (Brent Smiga) in a strategic move to align with the Jimenez Cartel. Fed up, Brenda finds herself caught in the crossfire of an escalating drug cartel war. Meanwhile, Epifanio struggles to keep his campaign moving while dodging public rumors of his link to the drug trade violence.
Out of options, Teresa and Brenda find themselves in a desperate situation, playing a dangerous extortion game. Camila sends James on a deadly mission.
Teresa, determined to escape and save Brenda, risks her life to protect the book by any means necessary. Meanwhile, in his campaign for Governor, Epifanio obtains new intel that changes everything.
