Álvaro Cervantes
as Carlos de Habsburgo
Blanca Suárez
as Isabel de Portugal
Félix Gómez
as Fernando Álvarez de Toledo
Laia Marull
as Juana I de Castilla
Mélida Molina
as Catalina de Aragón
Alex Brendemühl
as Enrique VIII
Ramón Barea
as Fadrique de Alba
Víctor Clavijo
as Francisco de Borja
Alberto San Juan
as Carlos de Borbón
José Luis García-Pérez
as Hernán Cortés
Susi Sánchez
as Luisa de Saboya
Alfonso Bassave
as Francisco I de Francia
Nathalie Poza
as Germana de Foix
Eric Balbàs
as Fernando de Habsburgo