Delroy Lindo
as Mr. Nancy / Anansi
Malachi Kirby
as Charlie Nancy / Fat Charlie
Malachi Kirby
as Spider
Amarah-Jae St. Aubyn
as Rosie Noah
CCH Pounder
as Mrs. Higgler
Fiona Shaw
as Maeve Livingstone
Grace Saif
as Daisy Day
Jason Watkins
as Graham Coats
Whoopi Goldberg
as Bird Woman
L. Scott Caldwell
as Mrs. Dunwiddy
Joy Richardson
as Mrs. Bustamonte
Lachele Carl
as Miss Noles