Aidan Turner
as Leonardo da Vinci
Matilda De Angelis
as Caterina da Cremona
Freddie Highmore
as Stefano Giraldi
James D'Arcy
as Ludovico Sforza
Alessandro Sperduti
as Tommaso Masini
Carlos Cuevas
as Salai
Antonio de Matteo
as Galeazzo Sanseverino
Massimo De Santis
as Rinaldo Rossi
Robin Renucci
as Piero da Vinci
Gabriel Lo Giudice
as Marco
Josafat Vagni
as Giulio
Flavio Parenti
as Bernardo Bembo
William Michael Roberts
as Luigi Niccolini
Giovanni Scifoni
as Father Luca Pacioli
Miriam Dalmazio
as Beatrice d'Este
Poppy Gilbert
as Ginevra de' Benci
Andrew Knott
as Alfonso
Max Bennett
as Cesare Borgia
Claudio Castrogiovanni
as Ramiro
Francesca Chillemi
as Margherita
Corrado Invernizzi
as Soderini