Peter Coyote stars as an agent who investigates the simultaneous return of 4400 people who went missing over several decades. In the opener, none of those returned have any memory of what happened and none have aged.
Tom and Diana investigate a supermarket employee who returned from his 18-month odyssey with enhanced strength and reflexes and is using his powers to combat crime in his neighborhood. Elsewhere, the pregnant Lily believes her baby can communicate with her; and Diana, concerned about 8-year-old clairvoyant Maia, invites the girl to live with her.
The public begins to turn on the 4400.
Firebombings threaten the 4400 when their names and addresses are made public.
Tom's son Kyle is taken into custody by Lyttel, and Diana offers to help bust him out. Elsewhere, Danny tries to win back Nikki.
