Lisa Whelchel
as Blair Warner
Mindy Cohn
as Natalie Green
Kim Fields
as Dorothy "Tootie" Ramsey
Nancy McKeon
as Jo Polniaczek
Charlotte Rae
as Edna Garrett
Mackenzie Astin
as Andy Moffett
Cloris Leachman
as Beverly Ann Stickle
Felice Schachter
as Nancy Olson
George Clooney
as George Burnett
Julie Anne Haddock
as Cindy Webster
Julie Piekarski
as Sue Ann Weaver
Pamela Adlon
as Kelly Affinado
Molly Ringwald
as Molly Parker
John Lawlor
as Steven Bradley
Ryan Cassidy
as Kevin Metcalf
Sherrie Krenn
as Pippa McKenna
Jenny O'Hara
as Emily Mahoney