After suffering a heart‑attack, Andy tells a young pregnant woman that in order to save her and her unborn child she must get a heart transplant. However, unexpected complications with the donor's family place the transplant in jeopardy.
Andy and Pam try to save an 18-year-old college student in need of a double lung transplant but run into a road block that might not allow her to be eligible for a new set of lungs.
After Andy convinces UNOS (United Network for Organ Sharing) to give a former drug addict a new heart, things take a turn when the patient disappears right before the surgery.
The team races to save a group of high school football players after a bus crash.
In order to save his life, Andy and Pam try a risky new procedure on his wife's Rena's partner, Cristadi, who suffers from an aortic aneurism.
Lisa becomes very attached to an 8-year-old boy who she witnesses being crushed by a ride at a fair.
Andy and Sophia treat a car crash victim named Victor dying from ALS who asks to be to taken off of life support so his organs can be used to save others. Meanwhile, David tends to a foster parent with pulmonary hypertension who refuses admission to the hospital.
The wife of a billionaire suffers the consequences after a setback leaves her without a new liver and her husband resorts to buying one on the black market. Meanwhile, a friend from Andy's past resurfaces.
When a bride is gunned down at her wedding, the team is sent to harvest her lungs to transplant into a college basketball player.
Andy is forced to make a tough decision when the wife of a man in need of the kidney transplant is not a suitable match. Meanwhile, Andy suspects that a recent patient is rejecting his new heart.
A firefighter must decide whether to be a living donor to her captain, a man who mistreated her. Meanwhile, Andy's uncle turns up with a stab wound and asks him not to report the incident out of fear that it will violate his parole.
Andy is upset when his rival, an arrogant heart surgeon with no bedside manner, returns to the hospital.
Andy puts his patient Kuol at the top of the donor list to receive a new heart after his condition takes a turn for the worse. However, his transplant is put in jeopardy when the cops threaten to seize the money that was raised for Kuo's surgery.
