22 Episodes · Premiered September 28, 2006 · Ended May 17, 2007
They tried to be friends. But their chosen paths set them on a collision course. The Clark Kent-Lex Luthor rivalry explodes into the fierce good-versus-evil battle fans have long expected. Adding to the rivalry: Lana Lang becomes Mrs. Luthor. Clark would be stunned to find out why she says yes. Green Arrow forms a Super Hero league. Will Clark join? Luthorcorp expands its dark experiments. Will an awesome Kryptonite-powered army be the result? The answers - and thrills - are here!
Clark is imprisoned in the Phantom Zone, deprived of his powers. Meanwhile, Lex/Zod keeps Lana captive so she can sire him an heir; Lois and Martha crash near the Fortress of Solitude, where Jor-El tells Martha how to kill Zod; and Chloe reunites with Jimmy Olsen.
Clark thinks he's developed a cold, but it turns out to be a symptom of a new superpower; Lois gets a job at the Inquisitor, a local tabloid; Lana moves in with Lex, who suspects someone is stalking him.
A guilt-ridden Lex throws a charity ball for the town and hires the All-American Rejects to perform; Clark and Chloe pursue a creature who uses male human bodies to spawn, and the hunt intensifies after the creature abducts Jimmy Olsen; Lois reluctantly agrees to go with Oliver Queen to Lex's ball.
The Green Arrow draws the attention of Lois after she sees him steal a rare diamond necklace off Martha's neck; Clark discovers Oliver Queen's secret; Lex mends fences with his father to test Lana's loyalty.
An old prep-school incident involving the apparent death of a schoolmate returns to haunt Lex and Oliver, and the consequences could be deadly.
Clark and Raya face another escapee from the Phantom Zone, Baern, who knows the secret of the Kryptonian Black Box and will be unstoppable if he accesses its power.
Lex is covertly involved in the production of an experimental drug that Oliver Queen is taking. It gives Oliver superhuman powers to heal himself, but the side effects prove dangerous.
Lex disappears in front of Lana's eyes but nobody, including Lionel and Lex's security team, seems to believe her; Clark finds another refugee from the Phantom Zone---and this one eats human bones.
An illegal immigrant from the nearby McNally farm seeks help from Clark, who soon discovers a sinister secret buried in the farm's cornfield, which had been bombarded during the last meteor shower.
The Planet's gossip columnist, Linda Lake, makes life miserable for Lana, Lex, Chloe and Clark; Lois begins to suspect a connection between Oliver and the Green Arrow; and Lex drops a bombshell on Clark.
The Green Arrow, Impulse, Aquaman and Cyborg try to destroy LuthorCorp's secret laboratory, but Impulse is captured and tortured by Lex, prompting the others to join forces as a team to rescue him.
Clark finds himself trapped in a strange alternate reality, where he is stripped of his powers and under observation at an insane asylum, about to undergo a procedure.
It's Valentine's Day in Smallville, where love blooms and hearts are broken, but not for the usual reasons---red kryptonite is infused into cosmetics, and that makes Lois and Clark a little crazy.
A revealing photograph of Lana is sent to her, making her realize that she's being stalked; Jimmy breaks up with Chloe, forcing her to reevaluate her feelings about Clark.
Clark and Chloe discover that a young man who was blinded in the meteor shower and has the ability to identify "meteor freaks" is being used by Lex to locate others with unusual abilities so Lex can experiment on them.
On the day of Lex and Lana's wedding, Lex receives a call from Dr. Langston, who threatens him; Lana has second thoughts; and Clark decides he should tell Lana his secret.
A Zoner called Titan turns up in a secret fight club that broadcasts its battles on the Internet. When Lois investigates, she's kidnapped and forced to participate, and Clark's attempt to save her sparks a surprising turnaround.
Chloe discovers she's being manipulated by someone with meteor-enhanced abilities. Meanwhile, Lana laments the loss of her child; and Chloe's mother is the subject of an experiment by Lex.
Lex and Clark are trapped in an underground maze that's rigged with explosives, and the two reveal secrets about each other that were best left unsaid.
Lana is shot after secretly meeting with Lionel at the Daily Planet. As Jimmy studies photos of the scene, he's knocked unconscious and dreams of a 1940s version of Smallville. Meanwhile, Clark discovers why Lana married Lex.
Lex's secret efforts to use DNA from meteor freaks to turn Wes Keenan into a "super soldier" may be exposed by a corrupt senator, so Lex sends Wes to kill him, but Lois sees everything and becomes Wes' next target.
In the sixth-season finale, Clark learns how Lionel got Lana to marry his son; Lana tells Lex that it's over; Martian Manhunter helps Clark stop Lex from finding the last Phantom Zone wraith, hoping to keep him from building his army of super soldiers; and Lois gets into serious trouble when she tries to investigate the secret lab.
