Scoot McNairy
as Walt Breslin
José María Yázpik
as Amado Carrillo Fuentes
Alejandro Edda
as Joaquin "Chapo" Guzman
Alfonso Dosal
as Benjamin Arellano "El Min" Félix
Manuel Masalva
as Ramon Arellano Félix
Diego Luna
as Miguel Ángel Félix Gallardo
Matt Letscher
as James "Jaime" Kuykendall
Gorka Lasaosa
as Hector Palma
Joaquín Cosío
as Ernesto-Fonseca "Don Neto" Carillo
Mayra Hermosillo
as Enedina Arellano Félix
Fernanda Urrejola
as Maria Elvira
Teresa Ruiz
as Isabella Bautista
Michael Peña
as Enrique "Kiki" Camarena Salazar
Gerardo Taracena
as Pablo Acosta
Tenoch Huerta
as Rafael Caro Quintero
Julio César Cedillo
as Comandante Guillermo González Calderoni
Aaron Staton
as Butch Sears
Alyssa Diaz
as Mika Camarena
Bobby Soto
as David Barron
Luisa Rubino
as Andrea Nuñez
Alberto Ammann
as Pacho Herrera
Jesse Garcia
as Sal
Alejandro Furth
as Ramon Salgado
Matt Biedel
as Daryl
Alberto Zeni
as Amat Palacios
Luis Gerardo Méndez
as Victor Tapia
Lorenzo Ferro
as Alex Hodoyan
Alberto Guerra
as Ismael "El Mayo" Zambada
Lenny Jacobson
as Roger Knapp
Miguel Rodarte
as Danilo
Jero Medina
as Ossie Mejía
Ernesto Alterio
as Salvador Osuna Nava
Alex Knight
as Kenny
Andres Londono
as Enrique Clavel
Kristen Lee Gutoskie
as Dani
José Zúñiga
as General Jesús Hector Rebollo
Flavio Medina
as Juan Ábrego
Beau Mirchoff
as Steve Whipple