Billy and El, scientists for the Human Investigation Team, put together a team of super-powered individuals to deal with a secret government project to create a neutron beam cannon.
After a friend of Billy and El is killed, they go on a search for a lost Mayan treasure with the map they were given by him. Their discovery could very well rewrite Mayan history.
Harry, genius bottle-washer at Humanidyne, cobbles together a transmitter from company discards - and makes contact with aliens. At least, that's what he thinks he's done. The reality is far more dangerous.
A man, who has never left his homeland, miraculously travels from one side of the ocean to the next on a wooden raft to reach the Space Shuttle in time. The Misfits desperately try to help, but he keeps wondering off from them.
Johnny is fascinated by a woman he's met, Gina. But whenever he meets her she disappears when he's not looking. At the same time some of the misfits believe to have seen a monster in the sewer system, so all of them go down again to investigate. They discover a young boy who's become unconscious due to supposedly bad air. Also at the same time a party is being planned for the opening of an exhibition of valuable relics from the Titanic at the museum. It turns out that Gina is working together with a group of criminals, who were planning on placing a bomb in the sewer ...
El's friend Eddie's closest friend is Donald the dolphin, with whom he can communicate using electronics. But when Donald produces a picture of a skeleton and two flamingos deep underwater, things get very dangerous for them both.
A meteor impacts on a farm and radiates the cows grazing there. All is well until they are converted into hamburgers and served, unknowingly, by Gloria to three Senior Citizens who develop powers. Shortly thereafter, problems arise.
Billy is reunited with an old friend from high school who, through Humanydine, enlists the help of the Misfits in his Top Secret mission. As the mission unfolds as do the secrets and dangers of Billy's friend.
Johnny's mechanic friend Lonnie has been having visions, and finds out he's a twin, separated at birth, to someone much more famous. When Dwayne goes missing, Lonnie takes his place, and finds himself in serious danger.
When a fellow scientist of Dr. Hayes takes a bunny from the test lab she broke into, the Misfits are faced with a race against time to stop the outbreak of a deadly new plague.
The Misfits agree to help a former German spy reunite with his daughter who he was separated from 25 years ago in Germany. To do it, they use their powers to stage a magic show for the athletes she came from the Soviet Union with.
Gloria's pen-pal Jaye, having stolen a bracelet, is the object of some unidentified assailants. In the following pursuit Gloria gets kidnapped instead, Billy and El get arrested, and Jaye manages to escape with Johnny.
The Misfits are pulled into the world of gambling once more when they uncover a plot by the manager of a basketball team to bet on his team to lose. This happens as his players purposely throw games.
When Billy attempts to break the world record for staying awake, he begins to have hallucinations concerning his past adventures. He finds himself in an alternate reality where all his friends have different personalities and different jobs.
Lovable loser Mort believes he can wrestle when Gloria helps him save an elderly couple from being attacked. Unfortunately, it's a Mob-controlled protection racket, making things dangerous for Mort and Gloria.
Billy Hayes is arrested on suspicion of treason when he is found holding a blender that contains a top-secret defense computer chip.
