While searching for Charlie, Alex finds a caterer who was caught in the crossfire; Grace's mother asks for a priest; Dana consults with Cassie about a male stripper.
Alex and Charlie are confused about their relationship; Alex and Maggie disagree about a car crash survivor; Dana is forced to treat an injured motorcyclist; Zach bothers Maggie about dating.
Alex makes a promise to a young girl on her birthday; Maggie organizes a surprise party for Alex; Cassie is forced to confront her fear of infectious diseases.
Tempers flare as Dev's med school rival arrives at the hospital; Alex puts her job in jeopardy to help save the life of an at-risk youth.
Alex pushes the limits to make sure a patient desperate for a liver transplant survives; the hospital's new CEO bans expensive surgeries.
Alex's alarm at home goes off; Alex and Maggie ask Charlie for his opinion on a patient's treatment; Zach is persuaded by a patient while transitioning the ER to an urgent care facility.
Alex and Maggie deal with a tough lawyer after surgical complications with their cancer study patient; with the E.R. now an urgent care facility, Zach and his team aren't equipped to handle an accident victim.
Charlie and Manny treat a couple; Maggie evaluates the interns; Billy asks Maggie to be his mentor; Dawn tries to get her Chief of Surgery position back.
The doctors rally together to try to save an unknown man who was struck by a subway train; Randal delivers a warning about Charlie's gift; Dr. Sydney Katz returns to town.
Alex tries to distract herself from her grief; Charlie and Shahir try to track down Alex's brother; Alex treats a young girl with kidney failure; Maggie and Sydney treat a young woman with an STI.
While Charlie tries to save a young man's life, he is haunted by a mischievous spirit.
Alex and Maggie work together to deliver a baby; Charlie treats a magician.
Alex tries to help a patient who hurt himself while breaking into a house; a friend of Dev's has been beaten by the police; A heart patient wishes to open an animal sanctuary.
Charlie struggles more than ever with his relationship to the spirit world after a spirit distracts him at the scene of an accident, resulting in the death of a child. Alex must convince a holistic "guru to have hernia surgery, but the woman does not want anesthetic because of a traumatic experience in her past. In the end, they compromise with an awake surgery. Dana enlists the help of two young filmmakers, who've been admitted to the hospital, to make an adoption video for Shahir.
The board questions the hospital staff about Charlie's behaviour; a patient convinces Alex to use new-age techniques; Shahir agrees to do an in-utero surgery.
Alex has to put her concerns for Charlie aside when a chance to perform a cancer surgery arises.
Alex and Charlie are planning their wedding when disaster strikes at a chapel, and they have to put their wedding on hold to save the life of a bride.
In the series finale, Drs. Reid and Harris rush to the scene of an accident involving a busload of teens.
