After being stabbed in the heart, Alex has a profound experience in the liminal space, while a desperate Charlie and Dawn race against the clock to save her life. Meanwhile, Joel is pulled in to the ER to treat a suicidal patient that tests his duty as a doctor, and Maggie makes a bold decision that changes her relationship with Gavin.
With her body still in a coma, Alex shares an emotional journey with Charlie in the spirit world as he 'ghost-doctors' a brain-dead mother-to-be. Meanwhile, Joel forms a tight bond with a lively drug addict while trying to treat his necrotic leg. Hope Zion Hospital also welcomes its new OB/GYN, Dr. Sydney Katz, who throws Maggie off her game.
Alex is awake but still not back to her old self, and Dawn has given strict orders for her recovery plan. Meanwhile, Charlie and Joel square-off over differing treatment options when two fused-together burn victims are brought into the ER. Maggie finds herself in a whirlwind of emotions triggered from the fallout of her miscarriage.
Alex returns to work and meets a new colleague. Meanwhile, Joel gets involved in a dangerous situation at a local clinic; and Gavin has a blissful experience.
Victims of a car accident, a mother and her son arrive at the hospital. Alex and Joel discover that the mother needs a transplant. The spirit of the mother wants Charlie to console her son.
During a lunar event, Alex asks Joel and Maggie for help on a patient with contradicting symptoms. Charlie encounters a patient who believes she is dead, and Zachary's son pays him a visit.
Dr. Hamza and Dr. Reid try to save the memory of a young woman suffering from Alzheimer's with a radical surgery.
Alex and Charlie team up on a teenage girl's double surgery; Joel spends a day at a clinic and joins in a search-and-rescue mission in a ravine. Meanwhile, Maggie gets on Dr. Katz's bad side.
The relationship between Alex and Joel is tested by a marathon surgery session involving an injured race-car driver. Meanwhile, Charlie has an eventful day off and a hospital "frequent flyer" keeps a number of doctors hopping.
Alex and Shahir operate on a patient who drilled his own head. Maggie suspects Dana's daughter is stealing painkillers. Meanwhile, Joel sleeps with Selena.
Alex gets caught between Dana and her daughter. Dawn and Melinda deals with a patient who intends to sue the hospital for malpractice. Charlie encounters an MMA patient and her rival.
News of Alex's pregnancy and the mystery of who the father is circles the hospital. Joel returns after his quick incarceration. Maggie studies for the board exam and deals with a patient who has a fear of doctors. Meanwhile, Alex and Dawn continue to deal with their patients in need of a heart donor.
Alex encounters a trapped teenager during a hike in the woods; a woman refuses to see anyone but Joel; an exotic dancer comes to the ER.
Alex and Maggie perform an intricate procedure; Joel thinks his dad is hiding something; Charlie suspects foul-play when he sees a boy and his grandmother.
Alex asks for help in diagnosing a teacher with a mysterious illness; Charlie must explain his actions; Dawn must make a big decision.
Alex and Charlie try to save the life of a man on the run; a spirit won't leave Alex alone; Maggie and Zach try to help a couple; Joel and Shahir help a bride walk down the aisle.
Alex and Dana try to save a single mother's life; a hockey player's mobility is at stake; Charlie gets advice on winning back Alex; Sydney comes clean.
At an off-site army base, Joel and Zach get in a precarious situation; a hypothermia victim fights for the life; Alex, Maggie and Rian write their Surgical Boards.
