Humberto Busto
as Conrado Higuera Sol "Don Sol"
Alejandro Aguilar
as Toño
Rodrigo Abed
as Amado Carrillo Fuentes (alias "El Señor de los Cielos")
Luis Fernando Peña
as Armando "Rayo" López
Juan Carlos Oliva
as Héctor Luis Palma Salazar (alias "El Güero Palma")
Rolf Petersen
as Ramón Avendaño
Carlos Hernán Romo
as Benjamín Avendaño
Héctor Holten
as President Carlos Salinas de Gortari
Diego Vásquez
as Ismael Zambada García (alias "El Mayo" and/or "Don Ismael")
Teté Espinoza
as Chío
Luis Rábago
as General Blanco
Dolores Heredia
as Gabriela Saavedra
Valentina Acosta
as Alejandra (Alejandrina María Salazar Hernández)
Marco de la O
as Joaquín "El Chapo" Guzmán