Craig T. Nelson
as Dr. Simon Chase
Kim Cattrall
as Dr. Amanda Mayson
Colm Feore
as Adm. Aaron Richland
Michael Reilly Burke
as Adam Puckett
Michael Michele
as Tauna
Matthew Carey
as Maxwell Bishop
Megalyn Echikunwoke
as Elizabeth
Blu Mankuma
as Rollie Gibson
John Aylward
as Ben Madiera
Giancarlo Esposito
as Lt. Thomas Peniston