Seth MacFarlane
as Captain Ed Mercer
Adrianne Palicki
as Commander Kelly Grayson
Penny Johnson Jerald
as Dr. Claire Finn
Peter Macon
as Lt. Cmdr. Bortus
Scott Grimes
as Lt. Gordon Malloy
Mark Jackson
as Isaac
J. Lee
as Lt. Cmdr. John Lamarr
Chad L. Coleman
as Klyden
Jessica Szohr
as Lt. Cmdr. Talla Keyali
Halston Sage
as Lt. Alara Kitan
Anne Winters
as Ensign Charly Burke