Melissa Benoist
as Kara Zor-El / Kara Danvers / Supergirl
Chyler Leigh
as Alexandra "Alex" Danvers
David Harewood
as Hank Henshaw / J'onn J'onzz / Martian Manhunter / John Jones
Katie McGrath
as Lena Luthor
Mehcad Brooks
as James "Jimmy" Olsen / Guardian
Jeremy Jordan
as Winslow "Winn" Schott
Jesse Rath
as Querl Dox / Brainiac-5
Nicole Amber Maines
as Nia Nal / Dreamer
Chris Wood
as Mon-El
Azie Tesfai
as Kelly Olsen
Andrea Brooks
as Eve Teschmacher
Julie Gonzalo
as Andrea Rojas
Calista Flockhart
as Cat Grant
Staz Nair
as William Dey
Floriana Lima
as Maggie Sawyer
Odette Annable
as Samantha Arias / Reign
Sam Witwer
as Ben Lockwood / Agent Liberty
Peta Sergeant
as Princess Nyxlygsptlnz
April Parker Jones
as Colonel Lauren Haley
David Harewood
as Hank Henshaw / Cyborg Superman
LaMonica Garrett
as Mar Novu / The Monitor