Timothy Dalton
as Sir Malcolm Murray
Eva Green
as Vanessa Ives
Harry Treadaway
as Dr. Victor Frankenstein
Josh Hartnett
as Ethan Chandler
Rory Kinnear
as The Creature
Billie Piper
as Brona Croft / Lily
Reeve Carney
as Dorian Gray
Danny Sapani
as Sembene
Simon Russell Beale
as Ferdinand Lyle
Helen McCrory
as Evelyn Poole
Patti LuPone
as Dr. Seward
Wes Studi
as Kaetenay