Edie Falco
as Jackie Peyton
Merritt Wever
as Zoey Barkow
Paul Schulze
as Eddie Walzer
Stephen Wallem
as Thor Lundgren
Peter Facinelli
as Dr. Fitch Cooper
Anna Deavere Smith
as Gloria Akalitus
Ruby Jerins
as Grace Peyton
Dominic Fumusa
as Kevin Peyton
Mackenzie Aladjem
as Fiona Peyton
Eve Best
as Dr. Eleanor O'Hara
Betty Gilpin
as Dr. Carrie Roman
Adam Ferrara
as Frank Verelli
Haaz Sleiman
as Mohammed "Mo-mo" de la Cruz