Renee has spent company money and time on a search and rescue team to discover what happened to Liam in the chamber. She is asked to cease or quit. She quits, convinced that Liam is alive. Juliet Street helps her put together a new search team.
On the mothership, Sandoval tries to deal with the Atavus to preserve himself. Renee wants to act, tries to convince Hubble that the Atavus exist and need to be terminated. Street doesn't trust Hubble and thinks they should just lay low.
Humans are brought aboard the mother ship for a joining with the Atavus to create hybrids. Renee tries to free Ra'jel. Hubble and Renee both become captives of Sandoval.
Renee is still having trouble getting anyone to believe her about the Atavus. She meets a man who tells her that people who live underground are disappearing, due to the Atavus. They find a chamber used to make hybrids.
Howlyn is completely obsessed with Renee. He and Sandoval bring Boone back to life to try to get to Renee. Howlyn transforms Boone's sister into a hybrid.
Renee breaks a serial killer who also happens to be a pathologist out of prison to help her determine a way to kill the Atavus. Juliet Street has difficulty agreeing with Renee's plan.
A former Doors employee who has been turned into a hybrid tells Renee to stop a project just before he dies. The project seems to be an attempt to create Atavus hybrids faster.
Renee has crystal that shows a map of where all the other Atavus hives are throughout the planet. She goes to Boone for help in destroying the hives before Howlyn can find them. Sandoval resurrects Zo'or to hunt Boone.
From a hive under Stonehenge, Renee and Street take an Atavus called Gren in his stasis chamber to the Antarctic to see if the cold will affect him. Gren tries to convince Street that most Atavus are peaceful and will not feed from humans.
An archaeologist uncovers an ancient tomb and portal where a female Atavus appears. Renee chases it through a portal to a monastery back in time. A monk follows Renee back to the present.
After an incident where Renee fails to save a mother from an Atavus attack, she suffers PTSD and needs a break. She and Juliet Street head to a spa, but when Renee claims to have seen an Atavus, Street believes she's just being paranoid.
The leader of a high school based Atavus fan club is targeted to become the leader of a youth movement for hybrids. Renee tries to save his girlfriend and stop other teens from following him.
Renee is suspicious when a friend's wife and other patients become comatose supposedly from allergic reactions to anesthesia. She suspects Sandoval when she sees hybrids at the hospital. She needs an Atavus blood sample to find an antidote.
Tate is captured and Juda is injured in an attack on a military facility. Renee makes a deal with Tate to release him. He returns with Juda's body, which they study to learn why it did not regenerate.
Renee seeks the assistance of a former boyfriend who is now an archaeologist as she attempts to follow a map she believes will get them to an Atavus stasis chamber.
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Renee teams up with Michaels to steal weapon schematics from the US Army. They must turn his team to their side to succeed. Howlyn finds Zo'or to see if she can control the mothership.
Renee and Sandoval stand off at a hive where an adult Atavus is killed, but Renee takes a young one back to Juliet Street. Howlyn commands Sandoval to find and kill the youth who turns out to be Howlyn's son.
Patrichio is broken out of jail, tried, and killed by a vigilante group called the "Preservationists" protesting the government's stance on the Atavus. Their next target is Renee. She chooses Michaels as her lawyer for the vigilante trial.
Juliet Street is drugged at the club and turned into a hybrid. Sandoval uses her to get information about a hybrid vaccine in development and raids the lab where it is being developed.
Renee and Michaels take one of his men to the hospital to receive the hybrid vaccination, but Michaels suspects something strange is going on. Ra'jel visits Renee to prepare her for the final conflict.
Renee follows Ra'jel's command to go to the mothership and Liam reappears to help her. They need to stop Howlyn from getting to his star ship and they need Yulyn's help to board the ship.
