Recent medical school graduate Emily Owens is now a first-year surgical intern at Denver Memorial Hospital and she is ready to leave high school persona of geeky-girl-with-flop-sweats behind her.
When a patient's life is in danger, Emily considers an unorthodox method to get a fast approval on a procedure; Micah finds someone new spending time with his mother during her chemotherapy.
The surgical interns face an impromptu medical quiz; Emily reluctantly agrees to speak to students about safe sex after an STD outbreak at a local high school.
Micah and Emily are baffled when a patient won't accept a kidney transplant from her new husband.
A patient embarrasses Emily; when a teenager needs a liver transplant and neither parent is a match, a stunning secret is revealed; Cassandra tries to get info on Will; Tyra sets Emily up with her ex.
When Emily and Tyra discover that an infant has a condition, the parents are forced to make a difficult decision; a religious patient's faith is shaken; Micah is upset when Will breaks protocol.
When the beloved hospital flower delivery man collapses, Emily is determined to diagnose his condition, but she is baffled at his reluctance to get treated.
When a woman injured in a car accident is brought to the ER, Will recalls painful memories; Emily's cancer patient refuses to have surgery; Will chooses Cassandra's studying method over Emily's.
Will assumes a patient dressed in a costume is having a psychotic episode, but Emily disagrees; Dr. Bandari realizes her marriage might be in trouble; Emily agrees to a blind date with Cassandra's friend.
After a year-long absence, Dr. Aquino returns to the hospital, but must make amends with Dr. Bandari before rejoining the staff; Emily tries to prove that Will was jealous of her recent date.
Emily, Will and Cassandra are asked to describe each other's flaws as they compete for a position as Dr. Bandari's research assistant; a daredevil with a rare disease is forced to change his life.
Emily runs triage in the E.R. when the hospital is inundated with bus crash victims; Cassandra questions Will's true feelings for Emily; Micah makes a bold decision.
Will starts to feel jealous when he finds out that Emily and Micah are dating; Tyra and Emily are faced with an unruly patient; Micah's sister visits after learning the truth about their mother.
