Hugh Laurie
as Dr. Gregory House
Robert Sean Leonard
as Dr. James Wilson
Omar Epps
as Dr. Eric Foreman
Jesse Spencer
as Dr. Robert Chase
Lisa Edelstein
as Dr. Lisa Cuddy
Jennifer Morrison
as Dr. Allison Cameron
Peter Jacobson
as Dr. Christopher Taub
Olivia Wilde
as Dr. Remy "Thirteen" Hadley
Kal Penn
as Dr. Lawrence Kutner
Odette Annable
as Dr. Jessica Adams
Charlyne Yi
as Dr. Chi Park
Amber Tamblyn
as Martha M. Masters