Naomi Watts
as Dr. Jean Holloway
Billy Crudup
as Michael Holloway
Sophie Cookson
as Sidney Pierce
Melanie Liburd
as Alexis Wright
Karl Glusman
as Sam Duffy
Lucy Boynton
as Allison Adams
Poorna Jagannathan
as Larin Inamdar
Brenda Vaccaro
as Claire Rogers
Brooke Bloom
as Rebecca Rogers